The RNA code: Nature's Rosetta Stone

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The RNA code: nature's Rosetta Stone.

Marshall Nirenberg and Heinrich Matthaei initiated their biochemical approach to elucidating the genetic code in 1959, 6 years following the discovery of the double helix structure of DNA (1). At the time, geneticists were using T4 bacteriophage mutagenesis/ reversion of plaque morphology toward the same goal by inferring that three mutations were needed to specify an amino acid (2). The geneti...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2014

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1404819111